Preparation and application of 3D solid structure high performance liquid chromatography fillers in the detection of phthalates

Materials of 3D structure for HPLC columns have been prepared. Silica spheres with high purity were first funetionalized Substance A and a range other substances, finally followed by quaternization iodomethane to form the final product. standard solution four certain phthalates was used verify chromatographic performance resulting packing materia1. Quantification analysis performed external method. Linear relationships found between peak areas mass concentrations in definite ranges, detection limits (3S/N) 5 mg·kg-1 low determination (10S/N) 10 mg·kg-1. Recovery rates obtained addition method 100.8~106.8% RSDs (n=6) less than 4%, which meeting requirement routine experiment.